SELF NANOEMULSIFYING DRUG DELIVERY SYSTEM THESIS

SELF NANOEMULSIFYING DRUG DELIVERY SYSTEM THESIS

More importantly the large quantity of surfactants in the formulations can induce GI irritations. This article has been cited by other articles in PMC. Sodium crosscarmelose was provided by Fluka, Germany and lactose was purchased from Akbarieh pharmaceutical Co Iran. The regression analysis did not show any significant relevancy between aspect ratio and studied formulation factors; while it is indicated that the sphericity could be affected by the factors. Solid self-emulsifying drug delivery system, Extrusion-spheronisation, Pellets, Loratadin.

Permanent link to OUR Archive version: Self nanoemulsifying drug delivery system thesis , review Rating: Development of solid self-nanoemulsifying granules SSNEGs of ondansetron hydrochloride with enhanced bioavailability potential. Microemulsion formulation for enhanced absorption of poorly soluble drugs. Details of shape analysis results are brought in Table 3.

The self-emulsification time is determined by using USP dissolution apparatus 2 at 50 rpm, where 0. The efficiency of self-emulsification could be estimated by determining the rate of emulsification and droplet size distribution. Each formulation weighed to be equivalent to 3 mg loratadin.

This finding could be primarily attributed to the effects of pellet components particularly crosscarmelose on selff water absorption into the pellets and improve interfacial surface between liquid SNEDDS and dissolution medium. After 30 minutes, samples were filtered through 0. The overall results of this study indicated that an improved formulation of loratadin SNEDDS pellets was successfully developed using the extrusion-spheronization technique.

self nanoemulsifying drug delivery system thesis

Int J Pharm Investig. Acknowledgments This study was a Pharm.

self nanoemulsifying drug delivery system thesis

SEDDS are normally prepared as liquid dosage forms or encapsulated in soft gelatin capsules 10 which have some limitations such as: Then the rotated SE pellets were sieved by mesh 60 sieve and weighed in order to determine friability. The pellets were produced by the following processes: Results and Discussion Preparation and characterization of SNE pellets Size distribution Acceptable loratadin SNE pellets were successfully prepared by extrusion-spheronization technique, using different factors and levels applied in this study.

  MWRA ESSAY CONTEST

The image analysis was based on the consideration that for a perfect xystem particle the aspect ratio shows the value of unity and values deviating from unity greater than 1 indicate the degree of spheroid elongation. This study was a Pharm.

The regression analysis did not show any significant relevancy between aspect ratio and studied formulation factors; while it is indicated that the sphericity could be affected by the factors. Details of shape analysis results are brought in Table 3.

Self nanoemulsifying drug delivery system thesis

The SPSS 16 software was employed for the experimental design and regression analysis of the data to evaluate the effect of the variables on the responses. As we found out in this test and according to a previous study, adding the lactose had less effect on disintegration naanoemulsifying, but would be useful to improve appearance of the pellets.

In vitro dissolution profile of different pellets formulations are shown in Figure 3. The resulting SNE pellets exhibited uniform size and shape.

Self nanoemulsifying drug delivery system thesis

Three independent variables, including the percentage of Aerosil three levelsthe Crosscarmellose three levelsand the amount of liquid SNEDDS two levels were used Table 1. Emulsions upon system with various dissolution media should not show any phase separations or thesis of drug even after 12 hrs of storage, such formulation is considered as robust nanoemulsifying dilution Turbidity is a parameter for determination of droplet size and self-emulsification self 19 Fixed quantity of SEDDS is added to fixed quantity of suitable medium 0.

Can J Chem Eng. This result could be related to the smaller droplet size of F The delicery were carried out in triplicates and reported as mean droplet size and poly dispersity index PDI.

  ESSAY TUNGKOL SA FILIPINO WIKANG PAGKAKAISA

self nanoemulsifying drug delivery system thesis

According to the plot increasing amount of Aerosil, increasing the MDTis in accordance with the disintegration time of the pellets, while increasing crosscarmelose cause to decrease MDT. Stabilisation of emulsion droplets by fine powders.

The effect of increasing drug loads on the ability to keep SIM in solution was determined using the dynamic in vitro lipolysis. The pellets have improved appearance with fine pharmaceutical elegance, they can decrease the risk of dose dumping and local mucosal irritation, avoid powder dusting in the pharmaceutical industries, also their larger surface area enables better distribution in case of immediate release products.

Eur J Pharm Sci. In vitro dissolution profile of different pellets formulation.

Supersaturated Self-Nanoemulsifying Drug Delivery Systems (super-SNEDDS)

Self-emulsifying pellets prepared by wet granulation in high-shear mixer: Dissolution test The dissolution tests were carried out on, liquid SNEDDS, SE pellets, conventional pellets and tablets formed by drug powder in order to compare drug release profiles. Comparative bioavailability study in dogs of a self-emulsifying formulation of progesterone presented in a pellet and liquid form compared with an aqueous suspension of progesterone.

Conclusion The overall results of this study indicated that an improved formulation of loratadin SNEDDS pellets was successfully developed using the extrusion-spheronization technique.